GLP-1 medications like Semaglutide and Tirzepatide have completely changed the game for weight loss. With their ability to regulate appetite, stabilize blood sugar, and support significant fat loss, it’s no surprise more people are turning to these treatments than ever before. But with all the benefits come some real and sometimes frustrating side effects.
This blog post brings together real experiences from people just like you who are on a GLP-1 journey—sharing what they’ve felt, how they’ve managed it, and how they’re still pushing forward toward their goals.
1. Nausea & Vomiting Nausea is by far the most talked-about side effect. Some patients even experience vomiting early on. It usually improves as the body adjusts, but in the meantime, small bland meals, ginger, and avoiding high-fat foods can help.
Real experience: “The nausea isn’t pretty either but I’m 65 pounds down. 35 more to go till I can get my knees done.”
2. Constipation This one is surprisingly common. It’s not glamorous, but it’s real. Staying hydrated, adding fiber slowly, magnesium supplements, or gentle options like aloe can make a big difference.
Real experience: “Constipation for sure. I didn’t expect that to be the thing that slowed me down!”
3. Fatigue Many people report feeling unusually tired, even with adequate protein intake.
Real experience: “The fatigue is killing me. I can’t do simple tasks without being wore out. I’m eating 100g of protein daily but still struggling!”
We often encourage patients to check iron, B12, and hydration—and to give their body time to adjust to the new metabolic state.
4. Sulfur Burps A strange but very real side effect. These can be linked to slowed digestion. Smaller meals and watching fat intake may help, and some patients benefit from probiotics.
Real experience: “Nausea and sulfur burps. The combo is no joke!”
5. Hair Thinning Even with slow weight loss and sufficient protein, some experience noticeable hair thinning. It can be linked to rapid body changes or hormonal shifts.
Real experience: “Before you all come at me, I lost weight slowly and get plenty of protein. But my hair is still super thin. Rome wasn’t built in a day, though.”
Using hair-supporting shampoos, vitamins, and being patient can help promote regrowth over time.
6. Emotional Changes Some patients mention mood swings or feeling a little off. GLP-1s affect gut-brain communication, so it’s not entirely surprising. Being mindful of emotional health and speaking with a provider about it can be helpful.
Real experience: “Mood swings! I wasn’t expecting that at all.”
7. Migraines Headaches or migraines have been reported, often related to changes in hydration or eating patterns. Staying consistent with meals and increasing water intake may help reduce frequency.
Silver Lining: Mindful Habits Are Emerging
Interestingly, many patients share that even with the side effects, they’ve become more intentional about what they eat, how much they hydrate, and how they care for their bodies.
Real experience: “Loss of appetite. But I’m being forced to eat more mindfully and stay hydrated, so that’s a good thing!”
Bottom Line
If you’re on a GLP-1 or considering it, know this: You’re not alone in the side effects. But with the right strategies, support, and patience, most people find ways to manage them and stay on track toward their goals.
At Serenity Wellness & Weight Loss, we’re here to help you through every part of the journey—not just the victories, but the bumps too.
Have you experienced any of these side effects? Let us know what helped!